Novel C-alkylation Reaction of Condensed Thiophenes with Enaminones, Enaminonitriles, Ethoxymethylene Malononitrile, Aryl Vinyl Ketones and ω-Nitrostyrenes
نویسندگان
چکیده
منابع مشابه
Synthesis of Enaminones and Their Reaction with Dimethyl Acetylene Dicarboxylate
In present paper a simple procedure for the synthesis of enaminones without catalyst from 1,3-diketones that reacted with primary or secondary amines in ethanol as solvent, as well as the reaction of enaminones with unsaturated esters such as dimethyl acetylene dicarboxylate are reported.
متن کاملConvenient synthesis, anti-inflammatory, analgesic and ulcerogenic activites of some new bis-hydrazones and pyrazole derivatives.
The reaction of acid hydrazides (1a-c) with 2-chloro-1-(4-chlorophenyl)ethanone (2a) or 2-bromo-1-(4-bromophenyl)ethanone (2b) afforded bis-hydrazones 6a-d, while the reaction of la-c with 2-oxo-N-arylpropanehydrazonoyl chlorides (3a,b) furnished N-(aryl)propanehydrazonoyl chlorides 8a-c. The reaction of the latter chlorides with sodium benzenesulfinate furnished sulfones 11a-c. On the other ha...
متن کاملPalladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides.
A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.
متن کاملEnaminones as building blocks in heterocyclic syntheses: reinvestigating the product structures of enaminones with malononitrile. A novel route to 6-substituted-3-oxo-2,3-dihydropyridazine-4-carboxylic acids.
The reported structures of reaction products of enaminones with malononitrile in ethanolic piperidine are revised. A novel route to 2,3-dihydropyridazine-4-carboxylic acids 4a-c via reactions of 2-cyano-5-(dimethylamino)-5-arylpenta-2,4-dienamides 8a-c with nitrous acid or with benzenediazonium chloride is reported. Compounds 8a-c are converted to 1,2-dihydropyridine-3-carboxylic acid and 1,2-d...
متن کاملSelenium-containing heterocycles from isoselenocyanates: Base-catalyzed reaction of malononitrile with phenyl isoselenocyanate and bromoacetonitrile or alpha-halogenated ketones
The reaction of phenyl isoselenocyanate (1a) with malononitrile (= propanedinitrile) in DMF in the presence of Et3N leads to the intermediate ketene N,Se-hemiacetal 6a, which can be trapped with bromoacetonitrile or a-halogenated ketones 12a and 12b (Scheme 3). The products are [(alkylseleno)(phenylamino)methylene]malononitriles 10 and 13, which are obtained in good yield. In the case of the (2...
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ژورنال
عنوان ژورنال: Journal of Chemical Research
سال: 1999
ISSN: 1747-5198,2047-6507
DOI: 10.1177/174751989902300108